Cognitive Training at a Young Age Attenuates Deficits in the zQ175 Mouse Model of HD

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Cognitive Training at a Young Age Attenuates Deficits in the zQ175 Mouse Model of HD

Huntington's Disease (HD) is a progressive neurodegenerative disorder that causes motor, cognitive, and psychiatric symptoms. In these experiments, we tested if operant training at an early age affected adult cognitive deficits in the zQ175 KI Het (zQ175) mouse model of HD. In Experiment 1 we trained zQ175 mice in a fixed-ratio/progressive ratio (FR/PR) task to assay learning and motivational d...

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ژورنال

عنوان ژورنال: Frontiers in Behavioral Neuroscience

سال: 2016

ISSN: 1662-5153

DOI: 10.3389/fnbeh.2015.00361